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Phosphatidylserine (PS), as a phospholipid of the renal tubular epithelial cell membrane that can adsorb crystals, flips to the cell surface, enhancing the adhesiveness of stone crystals at the flipped sites ( Joshi et al
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Thus, OPH and NOPH are likely generated by the depletion of cysteine (not GSH per se) caused by its accelerated incorporation into GSH to cope with the increased GSH need for the detoxification of oxidants and glucose-catabolites (methylglyoxal, See below)
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