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This risk is not predicted by standard therapeutic drug monitoring ( Population prevalence varies by ethnicity (Figure 4D): approximately 0.19% (1 in 520) in a European pediatric cohort (Rahman et al., 2012)
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GnRHa can exert direct protective effects on the ovaries through peripheral GnRH receptors and significantly reduce the risk of ovarian failure in young women with severe SLE [149]
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