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These investigations employed diverse extraction methods and purification techniques, resulting in heterogeneous LBP profiles, which complicate cross-study comparisons and limit translational relevance
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Besides, berberine down-regulates the expression of acetylcholinesterase and inhibits acetylcholinesterase activity in Alzheimer’s disease model mice hippocampus which induced by heavy metals, in addition, berberine normalizes the production of inflammatory factors, such as tumor necrosis factor-alpha (TNF-α), IL-6, IL-1β ( Studies demonstrated that berberine contributed to AMPK signaling pathway activation and participate in anti-neuroinflammation
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