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Key Takeaways Dizziness occurs in 5.2% to 8.1% of Zepbound patients, primarily during the first 12 weeks and during dose escalations The mechanism involves both direct blood pressure effects and indirect dehydration from reduced fluid intake on a full stomach Most dizziness resolves within 3 to 6 weeks as the body adapts to tirzepatide's cardiovascular effects Orthostatic hypotension (dizziness when standing) is the most common pattern, not spinning vertigo The short answer Yes, dizziness is a documented side effect of Zepbound
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