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By inhibiting nicotinamide methylation at the expense of SAM, the molecule in the models increases the pool of nicotinamide available for NAD⁺ regeneration and spares S-adenosylmethionine
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As a supplement, NMN is much more orally bioavailable than NAD+.18 That, coupled with the fact that it’s just one step removed from becoming NAD+ in the salvage pathway — as opposed to NR, which must first be converted to NMN — means it’s theoretically the best choice for an NAD+ booster
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