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113 In addition, cyclophilin D (CypD), the most important mPTP-associated protein, binds to and activates the channel, and posttranslational modifications of this protein, such as phosphorylation and acetylation, have been described to modulate mPTP activity
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Using this compound as a marker of cobalamin deficiency, we have been able to demonstrate that cats and dogs with very low serum cobalamin do indeed have a significant tissue-level cobalamin deficiency (Figure 2)
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