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Medications After months or years of regular use, certain medications — most of which treat chronic illnesses — can trigger lupus symptoms including (x, x): Procainamide (x) Hydralazine (x) Quinidine (x) Sulfamethoxazole and trimethoprim, which contain sulfonamide to fight infections (x) Melatonin and ramelteon, sleep aids that may incite the immune system (x) Echinacea, which fights illness by exciting the immune system (x) Other Causes & Triggers of Lupus Bacterial and viral infections, especially German measles, Epstein-Barr virus and human parvovirus Endometriosis, oral contraceptives and hormone replacement therapy after menopause Tobacco Diets high in fat and calories and dietary zinc or iron (x, x, x) Lupus Treatment & Remedies Medication Though the symptoms are different, treatment for males and females is generally the same (x, x)