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This was also supported by the finding that the strength of memory for natural rewards is regulated by DNA methylation in VTA dopamine neurons ( Brain Cell Type-Specific DNA Modifications and Addiction Susceptibility Brain Cell Type-Specific Roles in Addiction Numerous brain regions are involved in addiction, including cortical (e.g., orbitofrontal cortex (OFC), prefrontal cortex (PFC), and cingulate cortex), striatal (e.g., dorsal and ventral striatum, including NAc), and other basal ganglia (e.g., substantia nigra, globus pallidus, and subthalamic nucleus) structures within the mesolimbic system (e.g., ventral tegmental area) (Figure 1)