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25 Whether enhanced total body lipogenesis that occurs in humans in response to chronic GC exposure reflects adipose tissue or hepatic lipogenesis is not known but, based on the higher contribution of hepatic lipogenesis to whole-body lipogenesis, 26 one would expect GC-induced lipogenesis to be primarily hepatic in origin
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Collagen and elastin related pathways Evidence sources : fibroblast and extracellular matrix studies, dermatology research Confidence : moderate on mechanisms Main caveats : more collagen in a dish does not automatically equal firmer or smoother skin in people
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