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As an illustration, chitosan-coated liposomes carrying salmon calcitonin (sCT) peptide have been reported to increase mucoadhesion and epithelial uptake, with in vivo (rat) studies showing enhanced bioavailability and prolonged plasma exposure in addition to a consistent residence-time and protection with the mechanisms outlined above [48]

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When it comes to the gut, apigenin “affects Enterococcus caccae cell wall/membrane synthesis and increases the incidence of protein misfolding… Bacteroides galacturonicus growth was also inhibited by apigenin…[and] apigenin promoted overall growth and diversity, lowered Firmicutes to Bacteroidetes ratio, and promoted production of short chain fatty acids, including butyrate, which is associated with health” (Wang et al., 2017)