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Furthermore, since FRDA is caused by insufficient, but functional, frataxin protein, epigenetic-based transcriptional re-activation of the FXN gene is an attractive therapeutic option
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Additionally, quercetin may promote inflammation by enhancing peroxisome proliferator-activated receptor C (PPAR-γ) activity, which indirectly mitigates inflammation and antagonizes NF-κB or the transcriptional activation of activator protein-1 inflammatory genes [61,63]
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