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The notion for combining entero-pancreatic hormone-based therapies for obesity treatment is supported by the efficacy of bariatric surgery on WL, an intervention leading to increased postprandial levels of multiple entero-pancreatic hormones [31, 32]
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Taken together, the pharmacological results are consistent and mechanistically coherent: in obese mice, a selective NNMT inhibitor reduces fat mass and improves metabolic markers, apparently by increasing adipocyte energy expenditure rather than by suppressing appetite
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