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We covered the origins of myofibroblasts as well as the roles of TGF-β in facilitating fibroblast transformation to myofibroblast, epigenetic regulators of fibrotic gene expression, ECM proteins, the fibrotic microenvironment, and the regulation of the immune system
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But the underlying products are still unapproved drugs, and the safety question that drove their unapproved status does not change because the FDA is going after the seller rather than the user
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