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Under normal reduction-oxidation conditions, physiological metabolism, especially via aerobic processes, produces a series of sub-products called reactive oxygen species (ROS) that include superoxides (O 2 − ), hydrogen peroxides (H 2 O 2 ), and hydroxyl radicals (OH − ) as part of the oxidation of metabolites
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The significant correlation between Kla-specific genes and lactate accumulation-related genes (e.g., P300, LDHA) reveals that Kla promotes BC progression and immune escape by affecting NK cell function and multiple signaling pathways (NOTCH, WNT, among others) (117)
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