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We propose the development of next-generation iron chelators specifically targeting bone or the regulation of the hepcidin pathway to mitigate iron overload, thereby alleviating osteoporosis associated with ferroptosis and providing novel strategies for treating iron metabolism-related diseases
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Furthermore, PNPLA2 in the heart is required to maintain the supply of FAs for cardiac function during thermogenesis, as PNPLA2 cardiac-specific deficient mice are cold intolerant (102)
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