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Vice versa, confronted with the permanent central venous occlusion, the therapy effect is starting centrally, from the occluded superior sagittal sinus, as a prime noxious event (note, instead increased positive pressure, BPC 157-rats presented the negative pressure values close to those noted in the superior sagittal sinus of the healthy rats)

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10.4 FLOW Trial: Extended Analysis and Practical Implications The Decision to Stop Early FLOW was stopped early by the independent data monitoring committee at the second planned interim analysis, when the pre-specified efficacy boundary for the primary composite endpoint was crossed