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granulosus TGR lacking the Grx domain [61] and mammalian TGR with Sec614Ser mutation or truncated TGR Cys613Stop [10] lack any residual GR activity suggesting that GSSG reduction occurs exclusively by the Grx domain in these orthologs
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This gives athletes and support personnel sufficient time to make themselves aware of the changes, review any medications they use on Global DRO, and apply for a Therapeutic Use Exemption (TUE) if required before the updated List comes into effect on 1 January 2026
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