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Inflammation and stress pathways intersect as well: NF-κB is upregulated during amino acid shortage via JNK/SAPK and ISR crosstalk, promoting survival and cytokine production, while p53 regulates amino-acid handling through targets like SLC7A11 (cystine uptake) and GLS2 (glutamine catabolism) to maintain redox balance
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The microRNAs (miRNAs), proteins, and metabolites in DCM may have complementary roles by jointly performing specific biological functions such as regulation of the functions and controlling different cellular processes and the formation of DCM
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