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Low doses of GH administration to 22-month-old Wistar rats for 8 weeks increased circulating IGF-1 levels, enhanced the synthesis of mitochondrial proteins and antioxidant enzyme activities (catalase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase (G6PDH)), and reduced oxidative damage (measured by the levels of 8-OHdG) in the skeletal muscle [23]
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