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Owing to the lack of gonadotropin support, accumulation of a large amount of leptin leads to spermatogenesis disorders and infertility and consequently to a decline in sperm quality (57)
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Inorganic sulfate levels in the plasma are retained by reabsorption of the filtered sulfate in the renal proximal tubule which requires the SLC13A1 (Solute Carrier Family 13 Member 1) which is a sodium-sulfate cotransporter (NaS1) located in the apical brush-border membrane and together with the SLC26A1-encoded sulfate-anion exchange transporter in the contra luminal basolateral membrane, allows for sulfate re-entry into blood circulation [[60], [61], [62]]
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