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These effects were associated with dose-dependent suppression of aquaporin-4 (AQP4) mRNA and protein expression in peri-lesional regions, suggesting that carvacrol may modulate water channel activity and BBB integrity to mitigate edema formation [46]
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The two major pathways for the degradation of proteins involve the selective elimination through the ubiquitin-proteasome system (UPS) and removal through chaperone-mediated autophagy (CMA) (128)
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