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at one year of said therapy, 42% maintained response and 31% were still in remission.5 Upadacitinib has the capacity to reduce proinflammatory cytokine production.6 Different clinical trials have shown that patients with moderate-to-severe Crohn’s disease respond favorably to induction and maintenance therapy with upadacitinib, compared with placebo.7–9 In different clinical trials, patients with perianal disease are excluded because they are more difficult to treat
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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Canakci V, Yildirim A, Canakci CF, Eltas A, Cicek Y, Canakci H
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