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NaBPC157 (without effect on basal normal values) compared with L-arginine has both a mimicking effect (impaired L-NAME-blood pressure increase, applied prophylactically and decreased already raised L-NAME values, given at the time of the maximal L-NAME-blood pressure increase (i.e., 10 minutes after L-NAME)) and a preventative activity (L-arginine-induced moderate blood pressure decrease was prevented by NaBPC157 pre-treatment)

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(Current Pharmaceutical Design, 2014) demonstrated that BPC-157 modulates the NO system in a context-dependent manner, upregulating it when levels are low and stabilizing it when levels are dysregulated