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Precisely, infliximab, adalimumab, and golimumab are anti-TNF-α monoclonal antibodies (mAbs), whereas certolizumab pegol is a pegylated single Fab’ antibody fragment and etanercept is a fusion protein, in which TNF receptor 2 is fused to the human IgG1-Fc domain
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Since preferred nitrogen sources, such as ammonia and nitrogen were not present when proline was used as the sole carbon and nitrogen source, catabolite repression of the proline utilisation pathway ( PUT1 and PUT2 ) would not have occurred 19
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