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Case summary A 67-year-old woman presented to the hospital with a 6-month history of fatigue and unintentional weight loss from loss of appetite and was found to have antibodies against intrinsic factor on laboratory workup after undergoing upper endoscopy
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The fundamental limitation of exercise mimetics was articulated in a 2017 perspective by Li and Laher in Clinical Pharmacology and Therapeutics titled "Exercise Mimetics: Running Without a Road Map," which explicitly cautioned that the therapeutic potential of exercise mimetics rests on preclinical rodent findings and that translation to humans involves substantial unknowns
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