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Additionally, inhibiting FAS in BMDCs by applying the fatty acid synthase inhibitor C75 or blocking the mitochondrial-cytosolic citrate shuttle can reduce lipid accumulation, resulting in the suppression of BMDC activation and proinflammatory functions in response to LPS stimulation[37, 70]
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Additionally, stress-induced hormonal changes, characterized by an increase in cortisol levels, have been linked to the acceleration of premature greying by affecting melanocyte stem cells
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