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Various factors contribute to their efficacy as an OA therapy, including its antioxidant properties, protection of cartilage integrity, promotion of cartilage regeneration, and the use of Mn-based NPs a drug delivery vehicle
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Their characterization by electrophysiological approaches revealed that they are mostly closed under basal conditions and activated by different stimuli that are also known to induce eryptosis: ROS, exposure to high extracellular osmolarity, or removal of extracellular Cl - and isosmotic replacement with gluconate activate the channel [98] and trigger eryptosis [90]
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