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This decline contributes to disrupted sleep architecture, impaired immune surveillance (melatonin receptors MT1 and MT2 are expressed on T-cells and NK cells), reduced antioxidant protection (melatonin scavenges hydroxyl radicals and stimulates glutathione peroxidase), and accelerated cellular aging
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The main targets for GH action are the liver, where it induces the release of both glucose and IGF-I, and adipose tissue, where it controls the release of fatty acids (8)
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