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This review first describes the molecular structure of intestinal TJs, then summarizes the regulation of the intestinal TJ structure and permeability by extracellular factors, such as cytokines, growth factors, pathogens, nutrients, and food factors, and finally discusses the involvement of intestinal TJs in health and disease pathogenesis
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Breakdown of plant cell wall components and tolerogenic antigen presentation in the small intestine depended on the bacterial microbiome, which was distinct from the bacterial species found in the large intestine and contributed to Treg induction [129]
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