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No human clinical trial data quantifies the precise acceleration rate in humans, and the direct translation of the 30% to 50% figure from rodent models to human tendon repair remains unconfirmed by controlled clinical research

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For E1, the higher abundance of hydroxylated E1 also resulted in an increased abundance of 2- and 4-MeOE1, although these increases did not seem to be proportional to those observed for the hydroxylated metabolites