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Moreover, the activation of glia cells has been reported in both AD patients and animal models, accompanied by an activated complement system and increased levels of chemokines and cytokines [30,32,33,34,35]
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Increased Constitutive Activity of μ-Opioid Receptors It has been suggested that prolonged exposure to opioid agonists results in an enhanced level of MOR constitutive signaling (i.e., coupling of the receptor to G protein activation in the absence of any drug) (Liu and Prather, 2001
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