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Analysis of transcript levels of genes involved in DNA repair revealed that the expression of BRIP1 , BRCA1 and BRCA2 , genes encoding elements of the homologous repair (HR) system, was reduced substantially by vemurafenib or trametinib in all cell lines except one, and this reduction was more pronounced in insulin-deprived cells (Figure 4C)
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Therefore, targeting the AR signaling pathway represents a promising therapeutic strategy for TNBC [178]
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